Cryptobiotix

Decipher
the gut

The gut is a black box where products are being transformed. At Cryptobiotix, we decipher this black box in the lab. We elucidate how ingested actives are affected by digestion and interact with the gut microbiome, impacting overall well-being. With innovative technologies and a dedicated team, we keep pushing the boundaries of preclinical research in the field.

Preclinical data
you can trust

Products intended to improve gut health frequently fail in clinical trials, due to unreliable data from in vitro models. Cryptobiotix was founded to bridge this gap by developing the ex vivo SIFR^® technology pipeline:

Uniquely validated to predict clinical outcomes
High throughput to investigate many conditions in parallel
Advanced data visualisation and interpretation

We understand your
R&D imperatives

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Services

At Cryptobiotix, we have redefined the approach to gut microbiome research. Utilising our innovative SIFR^® technology, we offer a solution that combines high throughput and validated predictivity.

By simulating gut conditions ex vivo, we overcome the limitations of traditional in vitro methods, providing actionable insights quickly and cost-effectively.
Our approach enhances biorelevance, increases throughput, and clarifies key findings through advanced data interpretation, revolutionising preclinical research.

SIFR^® technology

Systemic Intestinal Fermentation Research

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SIFR® in screening mode

In screening mode, Cryptobiotix employs high-throughput methods to swiftly evaluate numerous candidates, pinpointing those with the most promising attributes. This mode enables rapid assessment of factors like efficacy, safety, and gut microbiome compatibility.

SIFR® in prism mode

In prism mode, selected candidates undergo detailed characterization, analyzing their interaction with the gut microbiome to provide insights into mechanisms of action, efficacy, and clinical applications. This phase offers a deeper understanding of products, facilitating informed decision-making for further development.

Applications

We simulate the gastrointestinal tract of humans across many ages and physiologies (healthy, diseased) as well as animals. We have extensive experience investigating all types of products, from pure ingredients to complex matrices.

Gastrointestinal simulation model

Product types

Fibres & prebiotics

Probiotics & LBPs

Postbiotics & extracts

Drugs

Whole foods

Why work with us?

1. De-risk your product development

Predictive insights from the SIFR^® enhance your chances of clinical success and de-risk the chance of failure.

2. Gain unprecedented insights in your product

Unravel the mechanism of action of your products and understand how they can contribute to gut health and overall well-being.

3. Shorten time to market

Obtain accurate results and gain critical insights to move forward quickly with IP applications and regulatory dossiers.

Publications

Explore our research findings and insights into the gut microbiome. We’re committed to sharing our discoveries with the scientific community to advance knowledge in this field.

Prebiotic investigation of immunoglobulin

SIFR® predictive for clinical changes in gut microbiota composition

Long-chain dextran boosts diversity

Sweeteners for healthy and type-2 diabetes individuals

Probiotic modulation of the small intestine

Carrot RG-I, a precision prebiotic with consistent effect

Age-specific prebiotics: HMOs vs fructans

Synbiotic discovery: tributyrin & Lactobacillaceae

Meet our team

Cryptobiotix is a dynamic company, built around a team of dedicated individuals that share a common vision. Challenging the status quo, empowerment, doing what feels right, and curiosity for the unknown. Since 2021, our team grew to more than 10 employees, passionate about enabling discoveries that can improve lives.

Want to join our team?

Aurélien Baudot

CEO & CO-Founder

Aurélien loves both business and science. He thinks in terms of systems, and modularity is a key to his operational approach. He manages daily operations at Cryptobiotix and interacts with customers to frame their research questions into projects with clear deliverables.

Pieter Van den Abbeele

CSO & CO-Founder

Pieter is a seasoned microbiology expert with a knack for developing preclinical models and interpreting complex data. He is the driving force behind the innovation and robustness of our technology. He also coordinates all research projects from start to finish, and integrates the data we generate into carefully interpreted reports.

Lien Van den Bossche

Project Manager

Lien is an enthusiastic project manager who excels at coordinating and optimising our contract research project portfolio. Thanks to her, our projects are delivered on time, and sometimes even ahead of time.

Ingmar van Hengel

Business Development Manager

Ingmar built a impressive scientific and commercial career through the years across various fields within the biotech sector. He will be happy to address your research questions, either through a call or in person at conferences.