protein Archives

Cryptobiotix 4, Mar, 2023

Adult, Analyses, Application, Compositional changes, Digestion, Fermentative parameters, Host, Prebiotic, Product, SIFR, Technology, Type

Van den Abbeele et al, 2023, Microorganisms.

Various bovine plasma fractions were investigated for their prebiotic potential and mechanism of action. To ensure a biorelevant research, the colonic SIFR simulation was preceded by a digestion and absorption step. The immunoglobulin fraction exhibited the most pronounced prebiotic potential. It was used specifically by Bacteroides vulgatus, Lachnoclostridium edouardi and Coprococcus comes, leading to the production of health-promoting SCFA (acetate, propionate & butyrate).

SIFR® predictive for clinical changes in gut microbiota composition

14 April 2023

Lack of translatability of preclinical findings for the actual clinical outcome is a common problem in gut microbiome-focused product development. We introduce the SIFR technology as a high-throughput platform, predictive for in vivo compositional changes in gut microbiota for different fibre interventions (inulin, 2'FL, resistant dextrin).

Sweeteners for healthy and type-2 diabetes individuals

18 July 2023

Sweeteners are used as sugar substitutes to reduce the risk of chronic diseases related to high sugar intake, such as type 2 diabetes (T2D). Their impact on the gut microbiome is poorly understood. We used the validated, high-throughput SIFR technology to unravel their specific impact on healthy and type-2-diabetes gut microbiota.

Probiotic modulation of the small intestine

7 July 2023

The mode of action of probiotics is often poorly understood. Investigating the effects of probiotics on the small intestine's microbiota is particularly challenging, due to difficulties of sampling and the absence of predictive fermentation models. We employed the high throughput SIFR® technology to decipher the mode of action of probiotic Ecologic®825 in the small intestine.

Carrot RG-I, a precision prebiotic with consistent effect

24 April 2023

cRG-I, a precision prebiotic with consistent effect

Interpersonal differences in gut microbiota impact the success rate of product development. the predictivity of research outcomes. Using the predictive SIFR® technology, we observed that cRG-I, as a fermentable yet selective prebiotic, homogenised gut microbial composition and metabolite production, while inulin (low selectivity) and xanthan (high selectivity) increased interpersonal differences.

Prebiotic investigation of immunoglobulin