Lack of translatability of preclinical findings for the actual clinical outcome is a common problem in gut microbiome-focused product development. We introduce the SIFR technology as a high-throughput platform, predictive for in vivo compositional changes in gut microbiota for different fibre interventions (inulin, 2'FL, resistant dextrin) ...
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Interpersonal differences in gut microbiota impact the success rate of product development. the predictivity of research outcomes. Using the predictive SIFR® technology, we observed that cRG-I, as a fermentable yet selective prebiotic, homogenised gut microbial composition and metabolite production, while inulin (low selectivity) and xanthan (high selectivity) increased interpersonal differences ...
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HMOs and fructans were tested in parallel in the high-throughput, ex vivo SIFR technology. Age-related bifidogenic effects occurred, and health-promoting metabolites connected to gut health, immunity and the gut-brain axis were stimulated ...
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Tributyrin showed promises as prebiotic in a first study. To fully convert it to butyrate, a synbiotic discovery project was set-up, across 6 donors, leveraging the high throughput of the SIFR technology. The synergy was confirmed and a putative mechanism of action could be found ...
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Various bovine plasma fractions were investigated for their prebiotic potential. The SIFR was preceded by a digestion and absorption step. The immunoglobulin fraction exhibited the highest prebiotic potential, with strongest SCFA production (acetate, propionate & butyrate), through specific microorganisms (Bacteroides, Lachnoclostridium, Coprococcus) ...
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